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Hpc, Analytical ­ltracentrifugation, and a New Detector

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Functions of the 3' and 5' genome RNA regions of members of the genus Flavivirus.

The University of Texas Health Science Center's Borries Demeler developed the analytical ultracentrifugation technology that enabled recent insights into how the West Nile virus replicates using cell proteins.

Credit: Faith Singer-Villalobos

Recent insights by Georgia State University researchers into how the West Nile virus replicates using cell proteins were gained using analytical ultracentrifugation technology developed by the University of Texas Health Science Center's Borries Demeler.

He says the method involves spinning biopolymers and protein molecules at high speed to define interaction.

Demeler has designed analysis software used in conjunction with analytical ultracentrifugation to enable the extraction of all possible information from the available data.

"To do this, we developed very high-resolution analysis methods that require high-performance computing [HPC] to access this information," Demeler notes. "We rely on HPC. It's absolutely critical."

Demeler says his UltraScan software performs the bulk of the work, and the Texas Advanced Computing Center's Lonestar 5 supercomputer is a key resource. "The calculations that underlie the fitting of experimental data requires finite element solutions and esoteric optimization routines that require a lot of computational power," he notes.

From Texas Advanced Computing Center
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