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Human Brain Organoids Grown in Cheap 3D-Printed Bioreactor

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An organoid growing in a microfluidic bioreactor.

It is now possible to grow and culture human brain tissue in a device that costs little more than a cup of coffee.

Credit: MIT, IIT Madras

A human brain organoid was cultured in a week in a three-dimensionally (3D)-printed microfluidic bioreactor developed by researchers at the Indian Institute of Technology Madras (IIT Madras) and the Massachusetts Institute of Technology.

The ultra-cheap bioreactor consists of a $5 washable, reusable microchip containing wells where brain tissue grows. Nutrient fluids are automatically pumped through these channels, feeding the tissue.

The chip can be 3D-printed using the same kind of biocompatible resin used in dental surgery, while the bioreactors control the flow of nutrient fluid and purge waste through tubes in an enclosed incubator.

IIT Madras' Ikram Khan said, "My goal is to see this technology reach people throughout the world who need access to it for their healthcare needs."

From New Scientist
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Abstracts Copyright © 2021 SmithBucklin, Washington, DC, USA


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