A team led by researchers at the Massachusetts Institute of Technology (MIT) used deep learning to identify drug combinations that can fight COVID-19 by modeling interactions between drugs and known biological targets related to the virus.
The approach identifyied two new drug combinations: remdesivir and reserpine, and remdesivir and IQ-1S.
Said MIT's Wengong Jin, "By modeling interactions between drugs and biological targets, we can significantly decrease the dependence on combination synergy data. In contrast to previous approaches using drug-target interaction as fixed descriptors, our method learns to predict drug-target interaction from molecular structures. This is advantageous since a large proportion of compounds have incomplete drug-target interaction information."
The model is not limited to a single strain of SARS-CoV-2, and the researchers applied their approach to HIV and pancreatic cancer as well.
From MIT News
View Full Article
Abstracts Copyright © 2021 SmithBucklin, Washington, DC, USA
No entries found