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How the Brain Prepares to Think

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nitial configuration of the molecular dynamics simulations designed to investigate the nature of the primed state of synaptic vesicles.

Said University of Texas professor Jose Rizo-Rey, "This country was very successful because of basic research. Translation is important, but if you don't have the basic science, you have nothing to translate."

Credit: Jose Rizo-Rey, University of Texas Southwestern Medical Center

The University of Texas Southwestern Medical Center's Jose Rizo-Rey and colleagues used the Texas Advanced Computing Center's Frontera supercomputer to probe the physics of thought activation in the brain.

The researchers have generated all-atom molecular dynamics simulations to explore the nature of the primed state of synaptic vesicles, indicating specialized proteins are "spring-loaded" and awaiting calcium ions to induce fusion.

The models only simulate the first few microseconds of the fusion process, but Rizo-Rey posits that fusion should occur in that time.

Rizo-Rey said, "If I see how it's starting, the lipids starting to mix, then I'll ask for 5 million hours [the maximum time available] on Frontera" to record the spring-loaded proteins' trigger and the fusion/transmission process.

From Texas Advanced Computing Center
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Abstracts Copyright © 2022 SmithBucklin, Washington, DC, USA


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