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Mapping by Human Brain Project Advances Understanding of Neuroreceptor Organization

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The data revealed 97 new regions, bringing the total to 180.

A new map based on brain scan data collected by the Human Connectome Project.

Credit: Matthew F. Glasser, David C. Van Essen

Human Brain Project scientists in Germany, France, the U.K., and the U.S. have gained new insights into the arrangement of neurotransmitter receptors in the brain through a new mapping.

The researchers analyzed the density of neuroreceptors on thin in vitro brain sections from 109 areas in the macaque cortex via autoradiography.

They mapped this data with anatomical and functional data onto a common cortical space on the cortical surface of the Yerkes19 non-human primate model.

The researchers identified "two major axes of receptor organization [that] align with two different functional systems, namely the sensory-cognitive and the external-internal cognition networks," according to Nicola Palomero-Gallagher at Germany's Forschungszentrum Jülich.

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Abstracts Copyright © 2023 SmithBucklin, Washington, D.C., USA


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