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3D Printing Method Shows Promise for Repairing Brain Injuries

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The researchers demonstrated that neural cells can be 3D-printed to mimic the architecture of the cerebral cortex.

Tissue regenerative therapies, especially those in which patients are given implants derived from their own stem cells, could be a promising route to treat brain injuries in the future.

Credit: Getty Images

Scientists at the U.K.'s University of Oxford three-dimensionally (3D)-printed human neural cells to emulate the cerebral cortex's architecture.

The researchers differentiated human-induced pluripotent stem cells into neural progenitor cells to form two distinct layers, then suspended them in solution to produce "bioinks" for printing into two-layered brain tissue.

The 3D-printed tissues exhibited strong integration when implanted into mouse brain slices; their signaling activity corresponded with that of the host cells.

Said Oxford's Linna Zhou, "Our droplet printing technique provides a means to engineer living 3D tissues with desired architectures, which brings us closer to the creation of personalized implantation treatments for brain injury."

From University of Oxford (U.K.)
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Abstracts Copyright © 2023 SmithBucklin, Washington, D.C., USA


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