Scientists at the U.K.'s University of Oxford three-dimensionally (3D)-printed human neural cells to emulate the cerebral cortex's architecture.
The researchers differentiated human-induced pluripotent stem cells into neural progenitor cells to form two distinct layers, then suspended them in solution to produce "bioinks" for printing into two-layered brain tissue.
The 3D-printed tissues exhibited strong integration when implanted into mouse brain slices; their signaling activity corresponded with that of the host cells.
Said Oxford's Linna Zhou, "Our droplet printing technique provides a means to engineer living 3D tissues with desired architectures, which brings us closer to the creation of personalized implantation treatments for brain injury."
From University of Oxford (U.K.)
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